Clinical efficacy of intensity modulated radiotherapy syn -chronization TP chemotherapy combined with af-terloading radiotherapy for advanced cervical cancer / 中国基层医药

Objective To observe the clinical efficacy and adverse reactions of intensity modulated radio-therapy(IMRT)syn -chronization TP chemotherapy combined with afterloading radiotherapy for advanced cervical cancer.Methods 58 cases of advanced cervical cancer patients were randomly divided into the chemotherapy combi-nation with radiotherapy(observation group,30cases)and radiotherapy alone(control group,28cases),Both groups were treated with external IMRT combined with afterloading radiotherapy,patients of the observation group were accepted concurrent chemoradiotherapy for TP regimen,and the patents of the control group were only accepted radio-therapy,the short -term curative effect,adverse reactions of the two groups were compared.Results The effective rate of the control group was 71.4%,which of the observation group was 83.3%.the observation group short -term curative effect was better than that of control group,with a significant difference(χ2 =4.247,P 0.05)no serious.Conclusion It can allow the patients with advanced cervi-cal cancer to benefit from the concurrent chemoradiotherapy.

Clinical observation of the efficacy of intracavitary injection of endostar combined with chemotherapy on ma-lignant pleural effusion / 中国基层医药

Objective To study the efficacy and safety of intracavitary injection of endostar combined with chemotherapy of malignant pleural effusion.Methods 46 cases with malignant pleural effusion were divided into groups of intracavitary injection of endostar combined with chemotherapy of malignant pleural effusion (treatment group)and groups of intracavitary chemotherpy(control group)randomly,pleural effusion of the patients from the two groups were injected cisplatin(DDP)60mg into the thorax and 45mg of endostar,The same therapy applied to the control group except adding endostar,twice a week,in 2 -4 rounds,the efficacy and safety of the two groups were studied.Results The effective rate of the treatment groups was 58.3%,which was higher than 31.8%of the control group (χ2 =4.547,P<0.05).The improvement rate of quality of life was 75.0% in the treatment group,which was higher than 59.1% in the control group (χ2 =5.371,P<0.05).The toxicities of the treatment group were not increased significantly.Conclusion The therapy of intracavitary injection of endostar combined with chemotherapy of malignant pleural effusion is effective and secure.